Clinical efficacy of high-dose acyclovir in patients with human immunodeficiency virus infection: a meta-analysis of randomized individual patient data
Abstract
A meta-analysis of 8 randomized trials (1792 patients, 2947 patient-years of follow-up) showed that acyclovir (> or = 3200 mg/day) offered a significant survival benefit (P = .006 by log-rank test) in human immunodeficiency virus (HIV) infection. The treatment effect did not vary significantly in …
Keywords
meta-analysis
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
u.s. gov't
adult
female
male
P.H.S.
follow-up studies
dose-response relationship
drug
anti-hiv agents / therapeutic use*
hiv infections / drug therapy*
acyclovir / therapeutic use*
randomized controlled trials as topic*
pmid:9697714
doi:10.1086/515621
j p ioannidis
a c collier
m s youle
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119097
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