Sex differences in kappa opioid receptor antinociception is influenced by the number of X chromosomes in mouse
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Sex differences in kappa opioid receptor antinociception is influenced by the number of X chromosomes in mouse

Taylor AMW;Chadwick CI;Mehrabani S;Hrncir H;Arnold AP;Evans CJ;;
journal of neuroscience research 2020 pp. -
225
amw2020journalsex

Abstract

Kappa opioid receptor (KOR) agonists produce robust analgesia with minimal abuse liability and are considered promising pharmacological agents to manage chronic pain and itch. The KOR system is also notable for robust differences between the sexes, with females exhibiting lower analgesic response th …

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National Center for Biotechnology Information NCBI NLM MEDLINE pubmed abstract nih national institutes of health national library of medicine pmid:32731302 doi:10.1002/jnr.24704 anna m w taylor caylin i chadwick christopher j evans

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