Eosinophil degranulation in the respiratory tract during naturally acquired respiratory syncytial virus infection
Abstract
Eosinophil cationic protein (ECP), a cytotoxic protein contained in the granules of eosinophils, has been suggested as having an important role in the pathogenesis of asthma. To determine whether ECP plays a similar role in bronchiolitis, we tested samples of nasopharyngeal secretions, obtained from …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
u.s. gov't
Child
Infant
P.H.S.
preschool
bronchiolitis / physiopathology
respirovirus infections / physiopathology
pneumonia
viral / blood
respirovirus infections / blood
probability
j l kimpen
r garofalo
p l ogra
eosinophils / physiology*
respiratory syncytial viruses*
respiratory tract infections / physiopathology
eosinophil granule proteins
ribonucleases*
viral / physiopathology
nasopharynx / metabolism
oxygen / blood
partial pressure
bronchiolitis / blood
respiratory tract infections / metabolism*
bacterial infections / physiopathology
respiratory tract infections / blood
pmid:1731020
doi:10.1016/s0022-3476(05)80592-x
bacterial infections / metabolism
blood proteins / analysis
blood proteins / pharmacokinetics*
bronchiolitis / metabolism
cell degranulation* / physiology
eosinophils / metabolism
hypoxia / blood
pneumonia / metabolism
pneumonia / physiopathology
viral / metabolism
respirovirus infections / metabolism*
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Citation
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118810
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