Dendritic cell anergy results from endotoxemia in severe malnutrition
Abstract
Malnutrition predicts an increased risk of morbidity and mortality from infection. Defects in cell-mediated immunity, such as thymic atrophy, impaired cutaneous tuberculin responses, and reduced T cell mitogenesis in vitro, are well characterized. There has been no convincing mechanism proposed for …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
female
male
Child
Infant
Comparative Study
preschool
Cells
Cultured
severity of illness index
Cohort Studies
interleukin-12 / deficiency
hiv infections / immunology
malnutrition / immunology*
dendritic cells / immunology*
pmid:19625645
doi:10.4049/jimmunol.0803518
stephen miles hughes
beatrice amadi
david goldblatt
coculture techniques
dendritic cells / metabolism
dendritic cells / pathology*
down-regulation / immunology
endotoxemia / immunology*
endotoxemia / metabolism
endotoxemia / pathology*
hiv infections / metabolism
hiv infections / pathology
hla-dr antigens / metabolism
interleukin-10 / metabolism
malnutrition / metabolism
malnutrition / pathology*
up-regulation / immunology
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