Severe COVID-19 in the young and healthy: monogenic inborn errors of immunity?
Zhang SY;Zhang Q;Casanova JL;Su HC; ;;
nature reviews immunology2020Vol. 20pp. -
261
sy2020naturesevere
Abstract
Severe COVID-19 is rare in previously healthy individuals who are less than 50 years of age, affecting probably no more than 1 in 1,000 such infected individuals. We suggest that these patients may become critically ill because of monogenic inborn errors that disrupt protective immunity to SARS-CoV- …