Knockdown of peroxiredoxin V increases glutamate‑induced apoptosis in HT22 hippocampal neuron cells
Abstract
High concentrations of glutamate may mediate neuronal cell apoptosis by increasing intracellular reactive oxygen species (ROS) levels. Peroxiredoxin V (Prx V), a member of the Prx family, serves crucial roles in protecting cells from oxidative stress. The present study investigated the regulatory ef …
Keywords
Tumor
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
animals
pubmed abstract
nih
national institutes of health
national library of medicine
reactive oxygen species / metabolism
Apoptosis / drug effects
cell line
hu-nan sun
apoptosis / genetics*
peroxiredoxins / genetics*
extracellular signal-regulated map kinases / metabolism
gui-nan shen
pmid:29620243
doi:10.3892/mmr.2018.8826
lei liu
apoptosis inducing factor / metabolism
gene knockout techniques
glutamic acid / metabolism*
glutamic acid / pharmacology
pyramidal cells / drug effects
pyramidal cells / metabolism*
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