Chemoimmunotherapy for hemophagocytic lymphohistiocytosis: long-term results of the HLH-94 treatment protocol
Abstract
Hemophagocytic lymphohistiocytosis (HLH) used to have a dismal prognosis. We report the final results of HLH-94, the largest prospective diagnostic/therapeutic HLH study so far. The treatment includes immunosuppressive and cytotoxic therapy aiming at clinical remission, followed by HSCT in patients …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
female
male
adolescent
Child
Infant
Immunosuppressive Agents / administration & dosage*
Immunosuppressive Agents / adverse effects
newborn
preschool
Clinical Trial
follow-up studies
Survival Analysis
time factors
drug combinations
combined modality therapy
lymphohistiocytosis
hemophagocytic / diagnosis
maintenance chemotherapy
hemophagocytic / drug therapy*
immunotherapy / methods
pmid:21900192
pmc3208276
doi:10.1182/blood-2011-06-356261
helena trottestam
annacarin horne
histiocyte society
clinical protocols
cytotoxins / administration & dosage*
cytotoxins / adverse effects
hematopoietic stem cell transplantation
immunotherapy / adverse effects
hemophagocytic / mortality
hemophagocytic / therapy
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ID:
116962
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