Targeting RNA decay with 2',5' oligoadenylate-antisense in respiratory syncytial virus-infected cells
Abstract
Treatment of human cells with 2',5' oligoadenylate covalently linked to antisense (2-5A-antisense) results in the selective cleavage of targeted RNA species by 2-5A-dependent RNase L. Here we show that 2-5A-antisense containing stabilizing modifications at both termini are effective in suppressing t …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
RNA
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
u.s. gov't
P.H.S.
cell line
polymerase chain reaction
n m cirino
electrophoresis
agar gel
respiratory syncytial viruses / drug effects*
antiviral agents / pharmacology*
respiratory syncytial viruses / physiology
viral / metabolism*
virus replication / drug effects
binding sites
respiratory syncytial viruses / metabolism
pmid:9050883
pmc20021
doi:10.1073/pnas.94.5.1937
g li
r h silverman
adenine nucleotides / genetics
adenine nucleotides / pharmacology*
endoribonucleases / metabolism
nucleic acid conformation
oligonucleotides / genetics
oligoribonucleotides / genetics
oligoribonucleotides / pharmacology*
antisense / genetics
antisense / pharmacology*
messenger / metabolism*
viral proteins / metabolism
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116906
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