Systolic blood pressure rise among T2DM patients was main risk factor for cardiovascular disease. Objective of this study was to identify predictors of isolated systolic hypertension among T2DM patients at Jimma University Specialized Hospital, 2016. We conducted cross sectional study using simple random sampling and interviewer administered questionnaire. Isolated systolic hypertension is SBP ≥ 140 mmHg and < 90 mmHg. Data entered and analyzed using Epi Data and SPSS respectively. Predictor factor was declared at p < 0.05.A total of 315 T2DM took part. Prevalence of ISH was 27.6% [95% CI (22.7, 32.5%)]. One hundred sixty and two (51.4%) patients were males with mean age of 54.1 from 22 to 87 years. Male sex [AOR = 2.4, 95% CI 1.21-4.72, p = 0.012], unemployment [AOR = 3.22, 95% CI 1.48-7.03, p = 0.003], age of 47-55 [AOR = 2.63, 95% CI 1.03-6.70, p = 0.044], single [AOR = 2.26, 95% CI 1.13-4.51, p = 0.021], ≤ Grade 8 [AOR = 2.94, 95% CI 1.10-7.85, p = 0.03] and income (ETB) 501-800 [AOR = 21.9, 95% CI 7.62-63.1, p < 0.001], 801-1500 [AOR = 5.78, 95% CI 2.55-13.1, p < 0.001] and > 1500 [AOR = 4.23, 95% CI 1.74-10.30, p = 0.001] were significant factors of ISH. The health sector has to establish preventive strategies for ISH among T2DM patients by giving special attention to predictor factors.