Pharmacokinetic/pharmacodynamic parameters: rationale for antibacterial dosing of mice and men
Abstract
Investigations over the past 20 years have demonstrated that antibacterials can vary markedly in the time course of antimicrobial activity. These differences in pharmacodynamic activity have implications for optimal dosage regimens. The results of more recent studies suggest that the magnitude of th …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
review
animals
humans
pubmed abstract
nih
national institutes of health
national library of medicine
bacteria / drug effects
microbial sensitivity tests
anti-bacterial agents / administration & dosage*
anti-bacterial agents / pharmacology
fluoroquinolones
anti-bacterial agents / pharmacokinetics
w a craig
lactams
pmid:9455502
doi:10.1086/516284
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116261
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wa1998clinicalpharmacokinetic/pharmacodynamic
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