Comprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer
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Comprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer

Wang Y;Xu X;Maglic D;Dill MT;Mojumdar K;Ng PK;Jeong KJ;Tsang YH;Moreno D;Bhavana VH;Peng X;Ge Z;Chen H;Li J;Chen Z;Zhang H;Han L;Du D;Creighton CJ;Mills GB; ;Camargo F;Liang H;;
Cell reports 2018 Vol. 25 pp. -
327
y2018cellcomprehensive

Abstract

Hippo signaling has been recognized as a key tumor suppressor pathway. Here, we perform a comprehensive molecular characterization of 19 Hippo core genes in 9,125 tumor samples across 33 cancer types using multidimensional "omic" data from The Cancer Genome Atlas. We identify somatic drivers among H …

Keywords

Tumor National Center for Biotechnology Information NCBI NLM MEDLINE gene expression regulation humans pubmed abstract nih national institutes of health national library of medicine models prognosis research support non-u.s. gov't N.I.H. Extramural cell line han liang Base Sequence micrornas / genetics biological neoplastic mutation / genetics pmid:30380420 pmc6326181 doi:10.1016/j.celrep.2018.10.001 yumeng wang xiaoyan xu micrornas / metabolism neoplasms / metabolism* protein-serine-threonine kinases / metabolism* signal transduction* / genetics

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