Diminished primary CD8 T cell response to viral infection during protein energy malnutrition in mice is due to changes in microenvironment and low numbers of viral-specific CD8 T cell precursors
Abstract
Protein energy malnutrition (PEM) increases the incidence and severity of infection, causing morbidity and mortality in malnourished populations. Viral-specific cells are an important component of protective immunity. We hypothesized that reduction in the expansion of viral-specific cells and the mi …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
Inbred C57BL
animals
pubmed abstract
nih
national institutes of health
national library of medicine
research support
female
N.I.H.
Extramural
Protein-Energy Malnutrition / immunology*
Body Weight
time factors
transgenic
eating
janel hart chatraw
zoher f kapasi
cd8-positive t-lymphocytes / immunology*
epitopes
glycoproteins / immunology
pmid:18356339
doi:10.1093/jn/138.4.806
e john wherry
arenaviridae infections / immunology*
arenaviridae infections / virology
cd8-positive t-lymphocytes / cytology*
lymphocytic choriomeningitis virus / immunology*
stem cells / cytology*
stem cells / immunology*
substrate specificity
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116201
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