Insulin signaling displayed a differential tissue-specific response to low-dose dihydrotestosterone in female mice
Abstract
Hyperandrogenemia and hyperinsulinemia are believed to play prominent roles in polycystic ovarian syndrome (PCOS). We explored the effects of low-dose dihydrotestosterone (DHT), a model of PCOS, on insulin signaling in metabolic and reproductive tissues in a female mouse model. Insulin resistance in …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
Inbred C57BL
animals
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
female
N.I.H.
Extramural
organ specificity / genetics
dose-response relationship
drug
signal transduction / drug effects
signal transduction / genetics
pmid:29351485
pmc5966754
doi:10.1152/ajpendo.00195.2017
stanley andrisse
katelyn billings
sheng wu
dihydrotestosterone / pharmacology*
energy metabolism / drug effects
hyperandrogenism / genetics
hyperandrogenism / metabolism
hyperandrogenism / pathology
insulin / metabolism*
insulin resistance / genetics
muscle
skeletal / drug effects
skeletal / metabolism
organ specificity / drug effects
ovary / drug effects
ovary / metabolism
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116115
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