Comparison of single and combination antimicrobial agents for prevention of experimental gas gangrene caused by Clostridium perfringens
Abstract
The treatment of experimental gas gangrene caused by Clostridium perfringens was investigated by using combinations of antimicrobial agents. This study demonstrated that rifampin, penicillin, metronidazole, and clindamycin were all bactericidal against standard inocula (10(5) to 10(6) CFU). These an …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
animals
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
u.s. gov't
non-p.h.s.
female
male
Comparative Study
microbial sensitivity tests
drug therapy
combination
metronidazole / therapeutic use*
d l stevens
clindamycin / therapeutic use*
j e mitten
clindamycin / blood
clostridium perfringens / drug effects
penicillin g / blood
rifampin / blood
pmid:2882732
pmc174712
doi:10.1128/aac.31.2.312
b m laine
gas gangrene / drug therapy*
penicillin g / therapeutic use*
rifampin / therapeutic use*
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116093
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