National Center for Biotechnology Information NCBI NLM MEDLINE humans pubmed abstract nih national institutes of health national library of medicine logistic models prognosis treatment outcome research support non-u.s. gov't adult female male N.I.H. Extramural Depressive Disorder Major / psychology middle aged randomized controlled trials as topic severity of illness index antidepressive agents / therapeutic use* single-blind method pmid:30922100 doi:10.1176/appi.ajp.2018.18030355 manish k jha abu minhajuddin madhukar h trivedi ambulatory care bupropion / therapeutic use citalopram / therapeutic use major / drug therapy* irritable mood* mirtazapine / therapeutic use venlafaxine hydrochloride / therapeutic use