To analyze the content of publications within the medical Natural Language Processing (NLP) domain in 2018.Automatic and manual pre-selection of publications to be reviewed, and selection of the best NLP papers of the year. Analysis of the important issues.Two best papers have been selected this year. One dedicated to the generation of multi- documents summaries and another dedicated to the generation of imaging reports. We also proposed an analysis of the content of main research trends of NLP publications in 2018.The year 2018 is very rich with regard to NLP issues and topics addressed. It shows the will of researchers to go towards robust and reproducible results. Researchers also prove to be creative for original issues and approaches.