Arctigenin enhances the sensitivity of cisplatin resistant colorectal cancer cell by activating autophagy
Abstract
Arctigenin is the active content of arctium lappa that present anti-cancer abilities in various carcinomas. However, its role and underlying mechanism in drug-resistant colorectal cancer cells has not been addressed. The present study used SW480 and SW620 to established cisplatin-resistant colorecta …
Keywords
Tumor
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
humans
pubmed abstract
nih
national institutes of health
national library of medicine
cell line
drug resistance
antineoplastic agents / administration & dosage
apoptosis
doxorubicin / administration & dosage
multiple*
cell proliferation
pmid:31564411
doi:10.1016/j.bbrc.2019.09.086
yuzhen wang
li lina
li suoni
atp binding cassette transporter
subfamily b / metabolism
autophagy / drug effects*
caspase 3 / metabolism
caspase 9 / metabolism
cisplatin / administration & dosage*
colorectal neoplasms / drug therapy*
neoplasm*
furans / administration & dosage*
inhibitory concentration 50
lignans / administration & dosage*
oxaliplatin / administration & dosage
paclitaxel / administration & dosage
up-regulation
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114298
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