GIT1 contributes to autophagy in osteoclast through disruption of the binding of Beclin1 and Bcl2 under starvation condition
Abstract
Approximately 10-15% of all bone fractures do not heal properly, causing patient morbidity and additional medical care expenses. Therefore, better mechanism-based fracture repair approaches are needed. In this study, a reduced number of osteoclasts (OCs) and autophagosomes/autolysosomes in OC can be …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
animals
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
Fractures
Knockout
pmid:30546041
pmc6294144
doi:10.1038/s41419-018-1256-8
shu-jie zhao
fan-qi kong
jin fan
autophagy / genetics*
beclin-1 / genetics*
cell cycle proteins / genetics*
bone / genetics
bone / pathology
gtpase-activating proteins / genetics*
osteoclasts / metabolism
phosphorylation
proto-oncogene proteins c-bcl-2 / genetics*
starvation / genetics
starvation / pathology
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114058
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