Significance of FLT3-tyrosine kinase domain mutation as a prognostic factor for acute myeloid leukemia

Significance of FLT3-tyrosine kinase domain mutation as a prognostic factor for acute myeloid leukemia

Sakaguchi M;Yamaguchi H;Kuboyama M;Najima Y;Usuki K;Ueki T;Oh I;Mori S;Kawata E;Uoshima N;Kobayashi Y;Kako S;Tajika K;Shono K;Kayamori K;Hagihara M;Kanda J;Uchiyama H;Kuroda J;Uchida N;Kubota Y;Kimura S;Kurosawa S;Date K;Nakajima N;Marumo A;Omori I;Fujiwara Y;Terada K;Yui S;Wakita S;Arai K;Kitano T;Kakihana K;Kanda Y;Ohashi K;Fukuda T;Inokuchi K;;
international journal of hematology 2019 Vol. 110 pp. -
402
m2019internationalsignificance

Abstract

The prognostic significance of FLT3-tyrosine kinase domain (TKD) mutations remains unknown. To investigate the prognostic impact of FLT3-TKD, 676 de novo acute myeloid leukemia (AML), we retrospectively analyzed cases and conducted a review of the literature. Of the 676 de novo AML cases, 34 (5.0%) …

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