Linking binge alcohol-induced neurodamage to brain edema and potential aquaporin-4 upregulation: evidence in rat organotypic brain slice cultures and in vivo
Abstract
Brain edema and derived oxidative stress potentially are critical events in the hippocampal-entorhinal cortical (HEC) neurodegeneration caused by binge alcohol (ethanol) intoxication and withdrawal in adult rats. Edema's role is based on findings that furosemide diuretic antagonizes binge alcohol-de …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
animals
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
N.I.H.
Extramural
Rats
Sprague-Dawley
dentate gyrus / pathology
diuretics / pharmacology
entorhinal cortex / pathology
organ culture techniques
blotting
western
pmid:19236167
pmc2848832
doi:10.1089/neu.2008.0682
kumar sripathirathan
james brown
michael a collins
acetazolamide / pharmacology
alcohol drinking / metabolism*
alcohol drinking / pathology*
antioxidants / pharmacology
aquaporin 4 / metabolism*
brain edema / metabolism*
brain edema / pathology*
chromans / pharmacology
dentate gyrus / metabolism
entorhinal cortex / metabolism
furosemide / pharmacology
nerve degeneration / metabolism
nerve degeneration / pathology
oxidative stress / drug effects
sulfonamides / pharmacology
torsemide
up-regulation / physiology
water / metabolism
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112504
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