Acute ethanol administration oxidatively damages and depletes mitochondrial dna in mouse liver, brain, heart, and skeletal muscles: protective effects of antioxidants
Abstract
Ethanol metabolism causes oxidative stress and lipid peroxidation not only in liver but also in extra-hepatic tissues. Ethanol administration has been shown to cause oxidative degradation and depletion of hepatic mitochondrial DNA (mtDNA) in rodents, but its in vivo effects on the mtDNA of extra-hep …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
animals
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
male
Ethanol / toxicity*
DNA
inbred icr
brain / drug effects
liver / drug effects
blotting
pmid:11454938
a mansouri
c demeilliers
b fromenty
antioxidants / pharmacology*
southern
central nervous system depressants / toxicity*
mitochondrial / drug effects*
fomepizole
melatonin / pharmacology
mitochondria / drug effects*
mitochondria
heart / drug effects
muscle / drug effects
oxidants / toxicity
pyrazoles / pharmacology
thymidine / metabolism
ubiquinone / pharmacology
vitamin e / pharmacology
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Citation
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112116
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