Native human antibody to Shr promote mice survival after intraperitoneal challenge with invasive Group A Streptococcus.
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Native human antibody to Shr promote mice survival after intraperitoneal challenge with invasive Group A Streptococcus.

Nilanjana Chatterjee;Ya-Shu Huang;Kristin V Lyles;Julie E Morgan;Lawrence M Kauvar;Susanna F Greer;Zehava Eichenbaum;
The Journal of infectious diseases 2020 pp. -
134
chatterjee2020thenative

Abstract

A vaccine against the group A streptococcus (GAS) has been actively pursued for decades. The surface receptor Shr is vital in GAS heme uptake and provides an effective target for active and passive immunization. Here, we isolated human monoclonal antibodies (mAbs) against Shr and evaluated their efficacy and mechanism.

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