The pyrin inflammasome and the Yersinia effector interaction
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The pyrin inflammasome and the Yersinia effector interaction

Malik HS;Bliska JB;;
immunological reviews 2020 Vol. 297 pp. -
236
hs2020immunologicalthe

Abstract

Pyrin is a cytosolic pattern-recognition receptor that normally functions as a guard to trigger capase-1 inflammasome assembly in response to bacterial toxins and effectors that inactivate RhoA. The MEFV gene encoding human pyrin is preferentially expressed in phagocytes. Key domains in pyrin includ …

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National Center for Biotechnology Information NCBI NLM MEDLINE review pubmed abstract nih national institutes of health national library of medicine pmid:32721043 doi:10.1111/imr.12907 haleema s malik james b bliska

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