Drosophila Histone Demethylase KDM5 Regulates Social Behavior through Immune Control and Gut Microbiota Maintenance

Drosophila Histone Demethylase KDM5 Regulates Social Behavior through Immune Control and Gut Microbiota Maintenance

Chen K;Luan X;Liu Q;Wang J;Chang X;Snijders AM;Mao JH;Secombe J;Dan Z;Chen JH;Wang Z;Dong X;Qiu C;Chang X;Zhang D;Celniker SE;Liu X;;
cell host & microbe 2019 Vol. 25 pp. -
507
k2019celldrosophila

Abstract

Loss-of-function mutations in the histone demethylases KDM5A, KDM5B, or KDM5C are found in intellectual disability (ID) and autism spectrum disorders (ASD) patients. Here, we use the model organism Drosophila melanogaster to delineate how KDM5 contributes to ID and ASD. We show that reducing KDM5 ca …

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