Regular optimization techniques have been widely used in landslide-related problems. This paper outlines two novel optimizations of artificial neural network (ANN) using grey wolf optimization (GWO) and biogeography-based optimization (BBO) metaheuristic algorithms in the Ardabil province, Iran. To this end, these algorithms are synthesized with a multi-layer perceptron (MLP) neural network for optimizing its computational parameters. The used spatial database consists of fourteen landslide conditioning factors, namely elevation, slope aspect, land use, plan curvature, profile curvature, soil type, distance to river, distance to road, distance to fault, rainfall, slope degree, stream power index (SPI), topographic wetness index (TWI) and lithology. 70% of the identified landslides are randomly selected to train the proposed models and the remaining 30% is used to evaluate the accuracy of them. Also, the frequency ratio theory is used to analyze the spatial interaction between the landslide and conditioning factors. Obtained values of area under the receiver operating characteristic curve, as well as mean square error and mean absolute error showed that both GWO and BBO hybrid algorithms could efficiently improve the learning capability of the MLP. Besides, the BBO-based ensemble surpasses other implemented models.