Extensive identification and analysis of conserved small ORFs in animals

Extensive identification and analysis of conserved small ORFs in animals

Mackowiak SD;Zauber H;Bielow C;Thiel D;Kutz K;Calviello L;Mastrobuoni G;Rajewsky N;Kempa S;Selbach M;Obermayer B;;
Genome biology 2015 Vol. 16 pp. -
440
sd2015genomeextensive

Abstract

Taken together, we identify hundreds of previously unknown conserved sORFs in major model organisms. Our computational analyses and integration with experimental data show that these sORFs are expressed, often translated, and sometimes widely conserved, in some cases even between vertebrates and inv …

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