Kinetics of Chemical Processes in the Human Brain. The Cholinergic Synapse-Mechanisms of Functioning and Control Methods.
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Kinetics of Chemical Processes in the Human Brain. The Cholinergic Synapse-Mechanisms of Functioning and Control Methods.

Varfolomeev, S D;Bykov, V I;Tsybenova, S B;
doklady biochemistry and biophysics 2020 Vol. 492 pp. 147-151
222
varfolomeev2020kineticsdoklady

Abstract

In the framework of the kinetic model, the functioning of the cholinergic synapse is considered. The results of mathematical modeling of changes in the level of acetylcholine, induced pH impulse, the influence of the frequency of impulse transmission and inhibition of acetylcholinesterase are presented. Physicochemical explanation for a number of important physiological phenomena, such as neuromuscular paralysis, the molecular mechanism of neurological memory, and actions of nerve poisons and toxins, is given.

Keywords

kinetic model human brain acetylcholine botulinum toxin catalytic activity of enzyme cholinergic synapse dynamics of process frequency of impulse transmission inhibition of acetylcholinesterase neurological memory neuromuscular contraction synaptic cleft

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DOI:
10.1134/S1607672920030126

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