Evaluation of rapid antigen test for detection of SARS-CoV-2 virus.

Evaluation of rapid antigen test for detection of SARS-CoV-2 virus.

Mak, Gannon Ck;Cheng, Peter Kc;Lau, Stephen Sy;Wong, Kitty Ky;Lau, C S;Lam, Edman Tk;Chan, Rickjason Cw;Tsang, Dominic Nc;
journal of clinical virology : the official publication of the pan american society for clinical virology 2020 Vol. 129 pp. 104500
186
mak2020evaluationjournal

Abstract

The rapid diagnosis of Coronavirus Disease 2019 (COVID-19) patients is essential to reduce the disease spread. Rapid antigen detection (RAD) tests are available, however, there is scanty data on the performance of RAD tests.To evaluate the performance of the commercially available BIOCREDIT COVID-19 Ag test and compare it with RT-PCR for detecting Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virus. Analytical sensitivity for the detection of SARS-CoV-2 virus was determined for the RAD test using viral culture and RT-PCR as reference methods. The RAD test was further evaluated using respiratory samples collected from confirmed COVID-19 patients. The results were compared with RT-PCR test.The detection limits between RAD test, viral culture and RT-PCR varied hugely. RAD was 10 fold less sensitive than viral culture while RAD was 10 fold less sensitive than RT-PCR. The RAD test detected between 11.1 % and 45.7 % of RT-PCR-positive samples from COVID-19 patients.This study demonstrated that the RAD test serves only as adjunct to RT-PCR test because of potential for false-negative results.

Citation

ID: 108161
Ref Key: mak2020evaluationjournal
Use this key to autocite in SciMatic or Thesis Manager

References

Blockchain Verification

Account:
NFT Contract Address:
0x95644003c57E6F55A65596E3D9Eac6813e3566dA
Article ID:
108161
Unique Identifier:
S1386-6532(20)30242-0
Network:
Scimatic Chain (ID: 481)
Loading...
Blockchain Readiness Checklist
Authors
Abstract
Journal Name
Year
Title
5/5
Creates 1,000,000 NFT tokens for this article
Token Features:
  • ERC-1155 Standard NFT
  • 1 Million Supply per Article
  • Transferable via MetaMask
  • Permanent Blockchain Record
Blockchain QR Code
Scan with Saymatik Web3.0 Wallet

Saymatik Web3.0 Wallet