At present, knowledge and information are considered vital resources for organizations, so some of them have realized that the creation, transfer and knowledge management are essential for success. This paper aims to demonstrate knowledge management as a transformative power for organizations using information systems; addressing the study from the interpretive perspective with the use of hermeneutical method in theory, documentary context. It is concluded that people living in a changing characteristic environment of the globalized world companies and motivated by the same company changes have accelerated in them the generation and acquisition of new knowledge and innovative capabilities to achieve competitive positions with the help of systems of information.