EI-2346, a novel interleukin-1beta converting enzyme inhibitor produced by Streptomyces sp. E-2346. I. Taxonomy of producing strain, fermentation, isolation, physico-chemical properties, and biological properties.
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EI-2346, a novel interleukin-1beta converting enzyme inhibitor produced by Streptomyces sp. E-2346. I. Taxonomy of producing strain, fermentation, isolation, physico-chemical properties, and biological properties.

Koizumi, Fumito;Hasegawa, Atsuhiro;Ochiai, Keiko;Ando, Katsuhiko;Kondo, Hidemasa;Yoshida, Mayumi;Matsuda, Yuzuru;Nakanishi, Satoshi;
the journal of antibiotics 2003 Vol. 56 pp. 985-92
321
koizumi2003ei-2346,

Abstract

EI-2346, a novel interleukin-1beta converting enzyme (ICE) inhibitor, was isolated from the culture broths of Streptomyces sp. E-2346. EI-2346 selectively inhibited the human recombinant ICE activity with an IC50 value of 3.9 microM, without inhibiting elastase and cathepsin B. EI-2346 also inhibited mature interleukin-1beta secretion from THP-1 cells induced by LPS with an IC50 value of 5.2 microM.

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