Determination of Monoamine Oxidase Inhibition and Antioxidant Effects of Various Herbal Teas
Dursun, Başak Yüce;
trakya university journal of natural sciences2017Vol. 18pp. 105-113
247
dursun2017determinationtrakya
Abstract
The
therapeutic properties of fruit teas are due to the polyphenolic flavonoids
they contain. Compounds inhibiting the flavoenzyme monoamine oxidase (EC
1.4.3.4, MAO) are known to be used as medicines in treatment of
neurodegenerative disorders such as Alzheimer’s and Parkinson’s diseases, and
in various neurological disorders. There are many studies about natural
compounds with antioxidant properties that prevent such diseases by reducing
oxidative stress which plays an important role in neurodegeneration. It is
therefore of particular importance to find double-acting products that can both
inhibit monoamine oxidase and reduce oxidative stress. In this study,
antioxidant activities of various fruit teas purchased from markets in Turkey
were determined by ferric-reducing antioxidant power, cupric reducing
antioxidant capacity and 1,1-diphenyl-2-picrylhydrazyl methods and their total
phenolic contents were revealed. MAO enzyme inhibitions of these tea infusions
was determined fluorometrically. The obtained results were compared with green
and black tea bag infusions. The results showed that antioxidant and MAO
inhibition properties of fruit tea samples were related to their total amount of
phenolic substances they contained. Pomegranate containing tea infusions had
higher antioxidant activity and phenolic content and exhibited high MAO
inhibition. The results also showed that a MAO–B selectivity varying between 2
to 3,5-fold existed in various tea infusions with the highest value in rose hip
tea. MAO inhibition abilities of tea infusions were demonstrated for the first
time in this present study which was based on the fact that phenolic substances
are responsible for MAO inhibition.