Synthetic Approaches to the New Drugs Approved During 2018.
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Synthetic Approaches to the New Drugs Approved During 2018.

Flick, Andrew;Leverett, Carolyn A;Ding, Hong Xia;McInturff, Emma L;Fink, Sarah;Helal, Christopher;Deforest, Jacob;Morse, Peter;Mahapatra, Subham;O'Donnell, Christopher J;
Journal of medicinal chemistry 2020
252
flick2020syntheticjournal

Abstract

New drugs introduced to the market every year represent privileged structures for particular biological targets. These new chemical entities (NCEs) provide insight into molecular recognition while serving as leads for designing future new drugs. This annual review describes the most likely process-scale synthetic approaches to thirty-nine new chemical entities approved for the first time globally in 2018.

Keywords

biological activity anti-tumor antivirus immune regulation structural modification degradation modification graft modification

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DOI:
10.1021/acs.jmedchem.0c00345

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