The article presents the author’s understanding of the need to revise the key principles of the new individualism, oriented to the construction of oneself, on one’s own life project, compatible with the belief in one’s own strengths and a strong civil position. It is noted that the view on the mo-dern problem of the personal self-design as a unique system of human lifecreation in the context of philosophical and social and humanistic systems can turn out to be productive, since while considering it appears as something beyond the power of active transformations and changes. The key to the correct interpretation of personality-based self-construction in the context of philosophical and social and humanistic systems of human life is the definitions of the philosophy of life belonging to F. Nietzsche, A. Bergson, G. Simmel, V. Dilthey, O. Spengler, H. Ortega y Gasset. The author’s interpretation of the phenomenon is grounded as a conceptual epigenesis of personality-based self-construction: «self-mastery», «an unceasingly selffulfilling force», «a mighty stream of creative formation», «the expansion of the world and the expansion of life relations». It is established that lifegiving effects can be achieved not only through work with semantic connections, but also as generalized structured principles: the way of «coming» into oneself, the motive, self-construction, ideology-sense formation, epistemology, temporary transspective, personality-based self-construction as an experiment life-creativity. The materials of the article can be integrated into various forms and types of further research on the psychology of the personality of modern man: the problem of personality-based self-construction in the space of the post-neoclassical paradigm; synergetic approach and the problem of personality-based self-construction; psychological and pedagogical practices of personality-based self-construction etc.