Integrating self-healing capabilities into soft electronic devices and sensors is important for increasing their reliability, longevity, and sustainability. Although some advances in self-healing soft electronics have been made, many challenges have been hindering their integration in digital electronics and their use in real-world conditions. Herein, an electronic skin (e-skin) with high sensing performance toward temperature, pressure, and pH levels-both at ambient and/or in underwater conditions is reported. The e-skin is empowered with a novel self-repair capability that consists of an intrinsic mechanism for efficient self-healing of small-scale damages as well as an extrinsic mechanism for damage mapping and on-demand self-healing of big-scale damages in designated locations. The overall design is based on a multilayered structure that integrates a neuron-like nanostructured network for self-monitoring and damage detection and an array of electrical heaters for selective self-repair. This system has significantly enhanced self-healing capabilities; for example, it can decrease the healing time of microscratches from 24 h to 30 s. The electronic platform lays down the foundation for the development of a new subcategory of self-healing devices in which electronic circuit design is used for self-monitoring, healing, and restoring proper device function.