The in vivo response of stem and other undifferentiated spermatogonia to the reversible inhibition of glial cell line-derived neurotrophic factor signaling in the adult
Abstract
Maintaining adequate numbers of spermatogonial stem cells is required for the production of the millions of sperm required for male fertility. To date, however, the mechanisms that regulate the size of this pool in the adult are poorly defined. Glial cell line-derived neurotrophic factor (GDNF) is r …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
animals
pubmed abstract
nih
national institutes of health
national library of medicine
research support
male
N.I.H.
Extramural
signal transduction*
stem cells / metabolism*
aging / physiology*
biomarkers / metabolism
stem cells / cytology*
testis / metabolism
testis / cytology
pmid:22232066
pmc3894909
doi:10.1002/stem.1028
joseph savitt
dolly singh
william w wright
amino acid substitution / genetics
cell differentiation*
glial cell line-derived neurotrophic factor / metabolism*
proto-oncogene proteins c-ret / metabolism
spermatogonia / cytology*
spermatogonia / metabolism
Citation
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268850
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