Expression profile of WNT molecules in prostate cancer and its regulation by aminobisphosphonates
Abstract
Skeletal metastases represent a frequent complication in patients with advanced prostate cancer (PCa) and often require bisphosphonate treatment to limit skeletal-related events. Metastasized PCa cells disturb bone remodeling. Since the WNT signaling pathway regulates bone remodeling and has been im …
Keywords
Tumor
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
gene expression regulation
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
male
aged
middle aged
cell line
in vitro techniques
enzyme-linked immunosorbent assay
blotting
western
reverse transcriptase polymerase chain reaction
wnt proteins / genetics
wnt-5a protein
neoplastic / drug effects
diphosphonates / pharmacology*
imidazoles / therapeutic use
Intercellular Signaling Peptides and Proteins / genetics
wnt proteins / metabolism*
Proto-Oncogene Proteins / metabolism
intercellular signaling peptides and proteins / metabolism
prostatic neoplasms / metabolism*
pmid:21344486
doi:10.1002/jcb.23070
sylvia thiele
martina rauner
lorenz c hofbauer
bone density conservation agents / therapeutic use
diphosphonates / therapeutic use
neoplastic / genetics
prostatic neoplasms / drug therapy
prostatic neoplasms / genetics
proto-oncogene proteins / genetics
wnt1 protein / genetics
wnt1 protein / metabolism
wnt4 protein
zoledronic acid
Citation
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268115
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