Background & Aims of the Study: Particulate matter pollutants have harmful effects on human health and can intensify mortality and disease. The aim of this study is evaluate to adverse health effects caused by exposure to PM 10 in Ahwaz, Bushehr and Kermanshah Cities during 2011. Materials & Methods: In this study, the Air Q2.2.3 model was used for estimated adverse health effects of exposure to PM 10 . Air Q model provided by the WHO European Centre for Environment and Health (ECEH). Air Q software proved to be a valid and reliable tool to estimate the potential short term effects of air pollution. Daily concentrations of PM 10 were taken from Department of Environment (ADoE). Then processing data’s and finally the cardiovascular and respiratory disease attributable to this pollutant were calculated.   Results: Results show that the non hospitalized patients suffer from the cardiovascular and respiratory diseases attributable to Pm 10 . The patients from Ahwaz allocate the highest rate of hospital admittance to themselves with 19% respiratory and 20% cardiovascular charts those from Bushehr refer to hospitals 14% for respiratory illness and 15% for cardiac disease and the subjects from Kermanshah go to the hospitals 12% for respiratory complications and 14% for cardiac failures. Conclusions: The results indicate a direct relationship between the concentration of PM 10 and health effects resulting from exposure to them. The highest rate belongs to Ahwaz becomes it has greater concentration of dusty air. Therefore, the higher relative risk value can depict mismanagement in urban air quality.