Generalized regression (GREG) estimation uses a model that assumes that the values of the variable of interest are not correlated. An extension of the GREG estimator to the case where the vector of interest has a positive definite covariance structure is presented in this article. This extension can be translated to the calibration estimators. The key to this extension lies in a generalization of the Horvitz-Thompson estimator which, in some sense, also assumes that the values of the variable of interest are not correlated. The Godambe-Joshi lower bound is another result which assumes a model with no correlation. This is also generalized to a vector of interest with a positive definite covariance structure, and it is shown that the generalized calibration estimator asymptotically attains this generalized lower bound. Properties of the new estimators are given, and they are compared with the Horvitz-Thompson estimator and the usual calibration estimator. The new estimators are applied to the Canadian Reverse Record Check survey and to the problem of variance estimation.