Inhibition of respiratory syncytial virus replication by antisense oligodeoxyribonucleotides
Abstract
Oligodeoxyribonucleotides targeted against respiratory syncytial virus (RSV) genomic RNA inhibited RSV replication in cell culture by an apparent antisense mechanism. HEp-2 cells were infected with RSV strain A2 and incubated in the presence of oligonucleotides. Virus replication was measured by enz …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
RNA
humans
pubmed abstract
nih
national institutes of health
national library of medicine
Cultured
Antigens
DNA
genome
Base Sequence
Viral
Molecular Sequence Data
respiratory syncytial viruses / growth & development
viral / biosynthesis
hn protein*
viral envelope proteins
respiratory syncytial viruses / drug effects*
antiviral agents / pharmacology*
respiratory syncytial viruses / physiology
cell division / drug effects
respiratory syncytial viruses / genetics
tumor cells
antiviral agents / toxicity
virus replication / drug effects
antisense / pharmacology*
oligonucleotides
viral proteins / biosynthesis
pmid:9037376
doi:10.1016/s0166-3542(96)01015-7
s jairath
p b vargas
r e kilkuskie
antisense / toxicity
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120446
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