Pioglitazone increases insulin sensitivity, reduces blood glucose, insulin, and lipid levels, and lowers blood pressure, in obese, insulin-resistant rhesus monkeys
Abstract
The antidiabetic effects of pioglitazone hydrochloride were evaluated in 6 spontaneously obese, insulin-resistant rhesus monkeys. The animals were studied during six successive 2-wk treatment phases separated by 2-wk rest periods: two placebo phases; 0.3, 1.0, and 3.0 mg.kg-1 x day-1 pioglitazone hy …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
animals
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
u.s. gov't
female
male
P.H.S.
Insulin / pharmacology*
macaca mulatta
body weight / drug effects
glucose tolerance test
insulin / blood*
insulin resistance / physiology*
pioglitazone
j w kemnitz
blood glucose / metabolism*
fasting
eating
thiazolidinediones*
pmid:8288044
doi:10.2337/diab.43.2.204
d f elson
m d meglasson
blood glucose / drug effects
blood pressure / drug effects*
feeding behavior / drug effects
heart rate / drug effects
hypoglycemic agents / pharmacology*
obesity / blood
obesity / physiopathology*
thiazoles / pharmacology*
tolbutamide / pharmacology
triglycerides / blood*
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118001
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