CD4+ T cells clear virus but augment disease in mice infected with respiratory syncytial virus. Comparison with the effects of CD8+ T cells
Abstract
Respiratory syncytial (RS) virus-specific T cell lines were derived from the spleens of BALB/c mice primed by intranasal infection with RS virus. The lines were expanded by repeated antigenic stimulation in vitro, and separated into CD4+ and CD8+ T cell-enriched fractions by immunomagnetic adhesion. …
Keywords
immunity
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
animals
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
u.s. gov't
female
Comparative Study
P.H.S.
cell line
Inbred BALB C
immunotherapy
bronchoalveolar lavage fluid / immunology
dose-response relationship
cellular
flow cytometry
respirovirus infections / immunology*
respirovirus infections / therapy
p j openshaw
respiratory syncytial viruses*
cytotoxicity
immunologic
t-lymphocyte subsets / immunology*
cd4-positive t-lymphocytes / immunology
cd8 antigens / immunology*
pmid:1351433
pmc1554527
doi:10.1111/j.1365-2249.1992.tb06482.x
w h alwan
f m record
adoptive
interleukins / analysis
weight loss
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116546
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