Amlexanox Downregulates S100A6 to Sensitize KMT2A/AFF1-Positive Acute Lymphoblastic Leukemia to TNFα Treatment

Amlexanox Downregulates S100A6 to Sensitize KMT2A/AFF1-Positive Acute Lymphoblastic Leukemia to TNFα Treatment

Tamai H;Yamaguchi H;Miyake K;Takatori M;Kitano T;Yamanaka S;Yui S;Fukunaga K;Nakayama K;Inokuchi K;;
Cancer research 2017 Vol. 77 pp. -
372
h2017canceramlexanox

Abstract

Acute lymphoblastic leukemias (ALL) positive for KMT2A/AFF1 (MLL/AF4) translocation, which constitute 60% of all infant ALL cases, have a poor prognosis even after allogeneic hematopoietic stem cell transplantation (allo-HSCT). This poor prognosis is due to one of two factors, either r …

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