In this research, some characteristic qualities of orange fruits such as vitamin C and acid content; weight; fruit and skin diameter; and red (R), green (G), and blue (B) values of the RGB color model for 70 samples were used to predict the taste of orange grown in Darab, southeast of Fars Province, Iran, by multiple linear regression (MLR) and adaptive neuro-fuzzy inference system (ANFIS). To use MLR, firstly the most important input data were selected, and then, the best model to predict the taste of orange was applied. In this research, methodology of ANFIS consisted of selection of dependent orange taste, fuzzification, fuzzy inference rule, membership function, and defuzzification process. The predictive capability of these models was evaluated by various descriptive statistical indicators such as mean square error () and determination coefficient (). The results showed that the prediction performance of the MLR model has a strong significant relationship between orange taste and vitamin C (0.897), red color (0.901), and blue color (0.713). Also, the results of ANFIS model showed that with low error for train and check data increased the most accuracy for prediction of orange taste. Moreover, the results indicated that the success rate of taste determination for orange is higher by using ANFIS compared to the MLR. This research was to provide valuable information for orange taste.