A genome-wide association study identifies genetic loci associated with specific lobar brain volumes

A genome-wide association study identifies genetic loci associated with specific lobar brain volumes

Lee, Sven J. van der;Knol, Maria J.;Chauhan, Ganesh;Satizabal, Claudia L.;Smith, Albert Vernon;Hofer, Edith;Bis, Joshua C.;Hibar, Derrek P.;Hilal, Saima;Akker, Erik B. van den;Arfanakis, Konstantinos;Bernard, Manon;Yanek, Lisa R.;Amin, Najaf;Crivello, Fabrice;Cheung, Josh W.;Harris, Tamara B.;Saba, Yasaman;Lopez, Oscar L.;Li, Shuo;Grond, Jeroen van der;Yu, Lei;Paus, Tomas;Roshchupkin, Gennady V.;Amouyel, Philippe;Jahanshad, Neda;Taylor, Kent D.;Yang, Qiong;Mathias, Rasika A.;Boehringer, Stefan;Mazoyer, Bernard;Rice, Ken;Cheng, Ching Yu;Maillard, Pauline;Heemst, Diana van;Wong, Tien Yin;Niessen, Wiro J.;Beiser, Alexa S.;Beekman, Marian;Zhao, Wanting;Nyquist, Paul A.;Chen, Christopher;Launer, Lenore J.;Psaty, Bruce M.;Ikram, M. Kamran;Vernooij, Meike W.;Schmidt, Helena;Pausova, Zdenka;Becker, Diane M.;Jager, Philip L. De;Thompson, Paul M.;Duijn, Cornelia M. van;Bennett, David A.;Slagboom, P. Eline;Schmidt, Reinhold;Longstreth, W. T.;Ikram, M. Arfan;Seshadri, Sudha;Debette, Stéphanie;Gudnason, Vilmundur;Adams, Hieab H. H.;DeCarli, Charles;
Communications biology 2019 Vol. 2 pp. 1-9
267
lee2019acommunications

Abstract

Sven van der Lee et al. report a genome-wide association study for lobar brain volumes in more than 16,000 individuals, with replication in nearly 9,000. They find 6 loci associated with occipital, parietal and temporal lobe volume, of which two were previously reported to associate with intracranial and hippocampal volume.

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