A vast study has shown a mixed result on the implications of a natural resource on growth and poverty. Theoretically, the Resource Curse Hypothesis stresses that natural resource serves as an obstacle for growth. However, the connection between human capital and poverty in OPEC member countries remain under-researched. To ensure inclusiveness in growth, it is essential to focus on human capital models that incorporate the components of poverty reduction. As a result, this study investigates the interactive relationship between human capital components and poverty reduction in OPEC member countries. It is a cross-country study of a panel fully modified least-squares of 12 countries within the OPEC region. The interactive effects of the components of human capital development have a long-run impact on poverty reduction in OPEC member countries. Besides, human capital components confirm a positive effect on poverty reduction. Thus, since human capital is a crucial determinant of improving economic growth, OPEC member countries should invest more on the quality of human capital through education and health to improve the living standard of people and societal welfare.