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Molecular Mechanisms and Therapeutic Strategies in Cutaneous Aging: A Comprehensive Review

Mayada Luqman
SciMatic Journal of Molecular Bio-Innovations · 2025-05-22 · DOI 10.5281/zenodo.23594940
Token #5255
✓ Verified on SciChain. The record below hashes to exactly the content hash stored on chain for token #5255.
Token#5255 of SciMatic Articles (ERC-1155), fixed supply 1,000,000
Contract0x0E596B4bb924937aA35D9b342A90347ed6F05eF8
Mint transaction0xd88763004d6a3e0b01bec1a54b0ff9f230fb2b70d38a4c804764700c7f7ab384 · block 12105277
Minted2026-10-02 04:55 UTC
Hash on chain0xf96c4259420bee0ec259e823afdbd61ffb96f4e2cc197975946d892b3d6c1dc3
SHA-256 of the record0xf96c4259420bee0ec259e823afdbd61ffb96f4e2cc197975946d892b3d6c1dc3
Article today Matches the anchored record.

Allocation at minting

HolderWalletMintedHolds now
SciMatic (10%) 0xc35709AB…277732 100,000 100,000
Mayada Luqman 0x6deaabd6…6C8C8E 900,000 900,000

The anchored record

Canonical JSON (keys sorted, no spaces, UTF-8). Its SHA-256 is the hash on chain.

{"abstract":"Skin aging is a complex biological process influenced by the interplay of intrinsic (chronological) and extrinsic (environmental) factors, culminating in visible changes such as wrinkles, laxity, and dyspigmentation. Intrinsic aging results from endogenous oxidative stress and cellular senescence, leading to reduced fibroblast proliferation, diminished collagen synthesis (notably types I and III), and fragmentation of elastin fibers. Concurrently, extrinsic aging, primarily mediated by chronic ultraviolet (UV) exposure (photoaging), exacerbates these effects through upregulation of matrix metalloproteinases (MMPs), degradation of extracellular matrix (ECM) components, and accumulation of abnormal elastin (solar elastosis). Additional contributors include decreased hyaluronic acid production, impaired barrier function, and accumulation of advanced glycation end products (AGEs). Modern anti-aging strategies target these pathways via retinoids, antioxidants, and cosmeceuticals aimed at collagen stimulation, oxidative stress neutralization, and epidermal rejuvenation. Understanding these mechanisms is critical for developing evidence-based interventions to mitigate cutaneous aging.","abstract_source":"original","authors":["Mayada Luqman"],"date":"2025-05-22","doi":"10.5281/zenodo.23594940","id":5255,"issue":1,"journal":{"issn":null,"name":"SciMatic Journal of Molecular Bio-Innovations"},"pdf_sha256":"ac5191009d05b2dce4f5cbac89491abebdd7722576306dbb4b2aa1b30b73d25a","schema":"scimatic-article/1","title":"Molecular Mechanisms and Therapeutic Strategies in Cutaneous Aging: A Comprehensive Review","volume":1}

Check it yourself

1. The record, from the token's own metadata:

printf '%s' "$(curl -s https://scimatic.org/nft/articles/5255.json | jq -r .canonical_record)" | sha256sum

2. The hash stored on chain (contentHash(5255)):

curl -s https://rpc.scimatic.net -H 'content-type: application/json' \
  -d '{"jsonrpc":"2.0","id":1,"method":"eth_call","params":[{"to":"0x0E596B4bb924937aA35D9b342A90347ed6F05eF8","data":"0xf3e0c2900000000000000000000000000000000000000000000000000000000000001487"},"latest"]}'

The two must be equal (the second with a 0x in front).