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Synthesis and Molecular Docking Study of bis-thiobarbiturate Derivatives as Effective Inhibitors of beta-glucuronidase

Dr. Hayat Ullah, Fahad Khan, Fazal Rahim, Zia Ur Rehman, Muhammad Taha, Abdul Wadood, Fawad Ahmad, Zainul Wahab, Imad Uddin, Khalid Zaman
Journal of Ongoing Chemical Research · 2019 · DOI 10.5281/zenodo.3576583
Token #163
✓ Verified on SciChain. The record below hashes to exactly the content hash stored on chain for token #163.
Token#163 of SciMatic Articles (ERC-1155), fixed supply 1,000,000
Contract0x0E596B4bb924937aA35D9b342A90347ed6F05eF8
Mint transaction0xa35e5afaa78fe47077ad2dd16cc5086134c2cde14db97862d1a2ba6641866992 · block 12096775
Minted2026-10-01 17:07 UTC
Hash on chain0xfb0d2fdff8ad7724070d7217eb3e38b3da653f93edee790aafcb2e31ee01199b
SHA-256 of the record0xfb0d2fdff8ad7724070d7217eb3e38b3da653f93edee790aafcb2e31ee01199b
Article today Matches the anchored record.

Allocation at minting

HolderWalletMintedHolds now
SciMatic (10%) 0xc35709AB…277732 100,000 100,000
Dr. Hayat Ullah 0x15737B62…664aCA 90,000 90,000
Fahad Khan 0x2A61357D…1C1882 90,000 90,000
Fazal Rahim 0x53De8145…e8Ba4C 90,000 90,000
Zia Ur Rehman 0xD5a1698a…55F925 90,000 90,000
Muhammad Taha 0x2F922e16…e35Baf 90,000 90,000
Abdul Wadood 0xB3cE3B5a…eA394A 90,000 90,000
Fawad Ahmad 0x714e7507…9e6Bfb 90,000 90,000
Zainul Wahab 0xd23C46f3…11FD62 90,000 90,000
Imad Uddin 0x455B3e56…4cE434 90,000 90,000
Khalid Zaman 0xB1e0e305…5B5800 90,000 90,000

The anchored record

Canonical JSON (keys sorted, no spaces, UTF-8). Its SHA-256 is the hash on chain.

{"abstract":"Bis-thiobarbiturate derivatives 1-15 have been synthesized and evaluated for their in vitro β-glucuronidase inhibitory potential. The structures of all compounds were confirmed through spectroscopic techniques such as EI-MS and 1HNMR. Compounds 13 (IC50 = 29.42 ± 0.61µM) showed potent β-glucuronidase inhibitory potential better than the standard inhibitor (D-saccharic acid 1, 4 lactone, IC50 = 48.4 ± 1.25 µM). The compounds 2 (IC50 = 48.45 ± 0.39 µM), 3 (IC50 = 53.12 ± 0.22 µM), 4 (IC50 = 55.12 ± 1.13µM) and 9 (IC50 = 49.84 ±1.46µM) showed b-glucuronidase inhibitory potential comparable to the standard inhibitor. Compounds 1 (IC50 = 68.45 ± 0.33 µM), 5 (IC50 = 61.18 ± 1.42µM), 6 (IC50 = 92.57 ±2.80 µM), 7 (IC50 = 61.27 ± 0.45 µM), 8 (IC50 = 62.85 ± 0.79µM), and 12 (IC50 = 77.56 ± 1.32µM) also showed good inhibitory potential. The remaining compounds are found to be completely inactive. The structure-activity relationship was established for these compounds. This study identified a novel class of β-glucuronidase inhibitors.","abstract_source":"original","authors":["Dr. Hayat Ullah","Fahad Khan","Fazal Rahim","Zia Ur Rehman","Muhammad Taha","Abdul Wadood","Fawad Ahmad","Zainul Wahab","Imad Uddin","Khalid Zaman"],"date":"2019","doi":"10.5281/zenodo.3576583","id":163,"issue":1,"journal":{"issn":"2651-4338","name":"Journal of Ongoing Chemical Research"},"pdf_sha256":"bb88454b69beba219674f3f44134fd4759489f8f42c14128979fb8097a904caa","schema":"scimatic-article/1","title":"Synthesis and Molecular Docking Study of bis-thiobarbiturate Derivatives as Effective Inhibitors of beta-glucuronidase","volume":4}

Check it yourself

1. The record, from the token's own metadata:

printf '%s' "$(curl -s https://scimatic.org/nft/articles/163.json | jq -r .canonical_record)" | sha256sum

2. The hash stored on chain (contentHash(163)):

curl -s https://rpc.scimatic.net -H 'content-type: application/json' \
  -d '{"jsonrpc":"2.0","id":1,"method":"eth_call","params":[{"to":"0x0E596B4bb924937aA35D9b342A90347ed6F05eF8","data":"0xf3e0c29000000000000000000000000000000000000000000000000000000000000000a3"},"latest"]}'

The two must be equal (the second with a 0x in front).