A mechanism for the suppression of estrogen production in polycystic ovary syndrome
Abstract
In polycystic ovary syndrome (PCOS), follicle development arrests in the early antral stage when aromatase expression in the granulosa cells (GC) would normally occur. Despite high intrafollicular concentrations of androstenedione and bioactive FSH, in vivo estrogen biosynthesis remains low. When GC …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
u.s. gov't
adult
female
adolescent
P.H.S.
Cells
Cultured
Polycystic Ovary Syndrome / metabolism*
testosterone / pharmacology
granulosa cells / drug effects
granulosa cells / metabolism
Aromatase / metabolism
pmid:8855823
doi:10.1210/jcem.81.10.8855823
s k agarwal
h l judd
d a magoffin
androstenedione / pharmacology
aromatase inhibitors
enzyme inhibitors
estradiol / biosynthesis
estrogen antagonists / metabolism*
estrogens / biosynthesis*
etiocholanolone / analogs & derivatives*
etiocholanolone / blood
etiocholanolone / metabolism
etiocholanolone / pharmacology
follicular fluid / chemistry
follicular fluid / physiology
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271413
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