Induction of ARF tumor suppressor gene expression and cell cycle arrest by transcription factor DMP1
Abstract
Expression of the DMP1 transcription factor, a cyclin D-binding Myb-like protein, induces growth arrest in mouse embryo fibroblast strains but is devoid of antiproliferative activity in primary diploid fibroblasts that lack the ARF tumor suppressor gene. DMP1 binds to a single canonical recognition …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
Kidney
animals
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
u.s. gov't
protein biosynthesis
P.H.S.
Cells
Cultured
cell line
Genes
genetic*
3T3 Cells
Transcription Factors / metabolism*
Base Sequence
Molecular Sequence Data
Promoter Regions
Recombinant Fusion Proteins / biosynthesis
gene expression regulation / drug effects
proteins / genetics*
embryo
recombinant proteins / biosynthesis
transfection
cell division / drug effects
fibroblasts / cytology
fibroblasts / physiology
cell cycle / drug effects
mammalian
M F Roussel
Tumor Suppressor Protein p14ARF
tumor suppressor protein p53 / metabolism
k inoue
c j sherr
pmid:10097151
pmc22408
doi:10.1073/pnas.96.7.3993
cell cycle / physiology*
cycloheximide / pharmacology
tumor suppressor*
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Citation
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271153
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