The RSC chromatin-remodeling complex influences mitotic exit and adaptation to the spindle assembly checkpoint by controlling the Cdc14 phosphatase
Abstract
Upon prolonged activation of the spindle assembly checkpoint, cells escape from mitosis through a mechanism called adaptation or mitotic slippage, which is thought to underlie the resistance of cancer cells to antimitotic drugs. We show that, in budding yeast, this mechanism depends on known essenti …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
Genes
signal transduction
cell cycle proteins / genetics
cdc
cell cycle proteins / metabolism
saccharomyces cerevisiae / metabolism
saccharomyces cerevisiae proteins / metabolism
saccharomyces cerevisiae proteins / genetics
saccharomyces cerevisiae / cytology
pmid:21098112
pmc2995168
doi:10.1083/jcb.201007025
valentina rossio
elena galati
simonetta piatti
chromatin assembly and disassembly*
mitosis / physiology*
phosphoprotein phosphatases / genetics
phosphoprotein phosphatases / metabolism*
protein tyrosine phosphatases / genetics
protein tyrosine phosphatases / metabolism
spindle apparatus / physiology*
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270708
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